414. Detection of Colonized Patients with Organisms Resistant to Carbapenems by a Fast Molecular Method at a Hospital in Nicaragua.

Abstract Background The resistance to carbapenems has significant implications regard the clinical outcomes of patients. Strategies detect colonized patients with carbapenems-resistant organisms are useful start isolation measures prevent intrahospital transmission. GeneXpert Carba-R is a fast molecular test rectal colonization by this type microorganisms. aim study was transferred from other countrywide hospitals in Nicaragua, have an epidemiological panorama circulation genes that confers carbapenems. Methods This retrospective cohort referral hospital (Hospital Dr. Fernando Vélez Paiz) Managua, Nicaragua. period between January 2020 and October 2020. Patients referred our ICU had been stayed more than 48 hours originating health-care center were recruited. Rectal swab processed identify any (NDM, KPC, VIM, IMP, OXA-48). An association evaluated. Results Eighty-nine included 27 (30.3%) them positive Xpert Carba-R. In four one gene detected. most frequent detected NDM (66.6%). Other VIM KPC. kind microorganims identified coming 9 6 capital city (Managua). Independent risk factors for resistant previous exposition class antibiotic (OR: 9.82; CI95%: 3.29-29.30) qSOFA ≥ 2 points at admission 7.36; 2.60-20.76). mortality 33.3% vs 9.6% control group (p=0.006), odds ratio 4.6 (CI95%: 1.46-14.90). Map Nicaragua showing wide distribution detection conferring Hospital Paiz Managua. Conclusion prevalence high. NDM. There presence these hospitals. use severity illness colonization. To be microorganism increased die. Disclosures All Authors: No reported disclosures.